منابع مشابه
Aplastic anemia with platelet thrombi.
7’. K., a 67 year old white female, was admitted to the Albert Einstein Medical Center, Southern Division, on September 6, 1949, with the chief complaint of fever and soremness of the sisouthi and gums. She was ap )areIit1y well until two weeks before admissioni when she developed a cough, sore throat amid a mild coryza. Shse was treated at home with aspirin, phemsacetins, co(leimse, caffeine, ...
متن کاملPlatelet thrombi in experimental cerebral infarction.
Cerebral infarction was produced in paralyzed, ventilated rats by a 30 min period of right common carotid artery occlusion combined with systemic hypoxia (Pao2 21-25 mm Hg). After 30 min the arterial clamp was removed and the animals were reoxygenated and allowed to survive for 1 min (6 animals), 30 min (12 animals), or 1 1/2 to 2 h (6 animals). The animals were reanesthetized and sacrificed by...
متن کاملHeparin Neutralization by Platelet-Rich Thrombi
Background Platelets contain several factors that inhibit heparin. This study was designed to assess the heparinneutralizing activity present in acute, platelet-rich arterial thrombi formed at sites of arterial injury in animals. Methods and Results Platelet-rich thrombi (n=3) were induced in pig coronary arteries by balloon catheter-mediated arterial injury. Soluble extracts were prepared from...
متن کاملFree hemoglobin: a boost to platelet thrombi.
hemorrhagic side effects of tPA. It is tempting to speculate that administration of FXIII might decrease tPA-induced hemorrhage by restoring FXIIIa that has been inactivated by plasmin, but further studies are necessary to test this hypothesis. Conflict-of-interest disclosure: Oregon Health & Science University and D.H.F. have a significant interest in Gamma Therapeutics, a company that may hav...
متن کاملPlatelet-targeted fibrinolysis enhances clot lysis and inhibits platelet aggregation.
BACKGROUND Although plasminogen activator therapy has been shown to reduce mortality in patients with severe myocardial infarction, several problems fuel the search for more potent and specific thrombolytic agents. METHODS AND RESULTS To explore the effect of plasminogen activator targeting to platelets, we covalently linked urokinase that had been modified with N-succinimidyl-3-(2-pyridyldit...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22105135